Development of Self Nano-dispersible Granules and Tablet Using Dry Nanosuspension Technique for Poorly Water-soluble Drugs
نویسندگان
چکیده
منابع مشابه
Nanonization strategies for poorly water-soluble drugs.
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limita...
متن کاملNanosized Technological Approaches for the Delivery of Poorly Water Soluble Drugs
A major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. If the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. Although some approaches are available for enhancing th...
متن کاملNovel Strategies for Poorly Water Soluble Drugs
Solubility of drug plays critical role in achieving the optimum therapeutic levels of the drug in blood and thus bioavailability. There are many drugs of various therapeutic categories fall in BCS class II and IV as they lack solubility. For all these drugs dissolution is the big hurdle for the absorption process. Present review’s focus is mainly on novel techniques of improving the solubility ...
متن کاملHydrotropic solubilization of poorly water-soluble drugs.
The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope. However, although solubility enhancements in the order of 100...
متن کاملLiquid-Crystal and Nano-Crystal Technology for Solubilization of Poorly Water Soluble Drugs
Of all the pharmaceutical compounds, about 40% are considered poorly water soluble and hence, the development of efficacious formulation is being halted. It has been shown that a drug should have a minimum aqueous solubility of 1% to avoid bioavailability problems. During preformulation study, sufficient time should be invested in order to improve the solubility of these kinds of drug. At the v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Society of Powder Technology, Japan
سال: 2019
ISSN: 0386-6157,1883-7239
DOI: 10.4164/sptj.56.389